ABOUT COURSE
This course provides a unique perspective on Auvelity (Dextromethorphan/Bupropion), a dual-action antidepressant that offers a novel approach for treating major depressive disorder (MDD) through its innovative mechanism, which combines dextromethorphan’s NMDA receptor modulation with bupropion’s norepinephrine-dopamine reuptake inhibition.
The curriculum covers essential topics for prescribers including:
- Indications
- Dosage and Administration
- Mechanism of Action
- Pharmacokinetics
- Warnings
- Drug Interactions
- Contraindications
- Augmentation Strategies
- Recommended Lab Tests
- Therapeutic Levels
- Overdose Management
- Tapering/Withdrawal
- Use in Special Populations-
- Pregnancy,
- Lactation,
- Renal Impairment,
- Hepatic Impairment,
- Cardiac Impairment,
- Elderly,
- Children and Adolescents
- Important pearls based on years of practice.
- This course is designed to equip mental health professionals with the expertise to optimize Auvelity therapy through effective and safe prescription and management practices.
LEARNING OBJECTIVES
Brand Names & Generic:
- Learn about brand names under which Auvelity is marketed.
- Learn about different generic names under which Auvelity is available in the market.
Indications:
- Learn the FDA-approved uses and potential off-label applications of Auvelity.
- Know the dosages of all potential off-label uses.
Dosage and Administration:
- Understand different medication forms and their administration.
- Implement appropriate dosage and administration guidelines for Auvelity in various clinical scenarios.
- Learn how to dose Auvelity correctly and identify usual dosage ranges.
Pharmacological Effects:
- Explore the mechanisms of Auvelity.
- Understand how Auvelity works in the brain to treat depression and other conditions.
- Discuss the impact of Auvelity on neurotransmitter levels and brain chemistry.
Pharmacokinetics:
- Absorption: Understand how Auvelity is absorbed in the body.
- Distribution: Learn about the distribution of Auvelity in the body.
- Metabolism: Discuss the metabolism of Auvelity.
- Elimination: Understand how Auvelity is eliminated from the body.
- Half-life: Know the half-life of Auvelity and its clinical significance.
Drug Interactions:
- Identify common drug interactions with Auvelity and strategies for managing them.
- Understand the mechanisms through which these interactions occur.
- Know which medications should be avoided with Auvelity due to drug interactions.
Common Side Effects:
- Learn about the most common side effects of Auvelity.
- Understand potential life-threatening side effects and how to manage them.
- Educate patients on what to expect and how to manage side effects.
Contraindications:
- Learn the conditions under which Auvelity should not be used.
- Understand the reasons why these conditions are contraindicated.
Best Augmenting Combos for Partial Response:
- Learn about the best augmenting combinations for patients with partial response to Auvelity.
- Discover effective strategies for augmenting Auvelity therapy.
- Evaluate the efficacy and safety of common augmentation strategies.
Recommended Lab Tests:
- Learn about recommended lab tests for safe and effective monitoring.
- Identify necessary lab tests to monitor patients on Auvelity.
- Interpret lab results to guide treatment adjustments.
Therapeutic Monitoring:
- Apply strategies for therapeutic monitoring to optimize treatment outcomes.
- Know about the therapeutic blood levels for Auvelity.
Overdose:
- Understand the signs and symptoms of Auvelity overdose.
- Recognize early warning signs of overdose and effective management strategies.
Tapering/Withdrawal:
- Apply best practices for tapering and withdrawal of Auvelity to minimize withdrawal symptoms.
- Follow the best protocols based on decades of clinical practice to safely taper Auvelity.
- Educate patients on the process and expected symptoms of tapering.
Usage with Special Populations:
- Gain insights into the unique considerations for prescribing Auvelity to special populations such as pregnancy, lactation, hepatic impairment, renal impairment, cardiac impairment, elderly, and children.
- Tailor Auvelity dosage for special populations considering their unique needs.
- Understand the risks and benefits of Auvelity use in these populations.
Important Pearls:
- Learn about essential clinical pearls to enhance practice and ensure patient safety.
- Understand the most important facts about Auvelity based on decades of clinical practice.
- Apply practical tips and experiences from clinical practice to improve patient outcomes.
