ABOUT COURSE
This Course provides extensive exploration of Deutetrabenazine,a (VMAT2) inhibitor,the first medication approved for treatment of Tardive dyskinesia.
The curriculum covers essential topics for prescribers including:
- Indications
- Dosage and Administration
- Mechanism of Action
- Pharmacokinetics
- Warnings
- Drug Interactions
- Contraindications
- Augmentation Strategies
- Recommended Lab Tests
- Therapeutic Levels
- Overdose Management
- Tapering/Withdrawal
- Use in Special Populations-
- Pregnancy,
- Lactation,
- Renal Impairment,
- Hepatic Impairment,
- Cardiac Impairment,
- Elderly,
- Children and Adolescents.
- Important pearls based on years of practice.
- This course aims to enrich the clinical capabilities of psychiatric nurse practitioners and other prescribers, providing the knowledge to prescribe and manage Deutetrabenazine therapy effectively and safely.
LEARNING OBJECTIVES
Brand Names & Generic:
- Learn about brand names under which Deutetrabenazine is marketed.
- Learn about different generic names under which Deutetrabenazine is available in the market.
Indications:
- Learn the FDA-approved uses and potential off-label applications of Deutetrabenazine.
- Know the dosages for all potential off-label uses.
Dosage and Administration:
- Understand different medication forms and their administration.
- Implement appropriate dosage and administration guidelines for Deutetrabenazine in various clinical scenarios.
- Learn how to dose Deutetrabenazine correctly and identify usual dosage ranges.
Pharmacological Effects:
- Explore the mechanisms of Deutetrabenazine.
- Understand how Deutetrabenazine works in the brain to reduce tardive dyskinesia.
- Discuss the impact of Deutetrabenazine on neurotransmitter levels and brain chemistry.
Pharmacokinetics:
- Absorption: Understand how Deutetrabenazine is absorbed in the body.
- Distribution: Learn about the distribution of Deutetrabenazine in the body.
- Metabolism: Discuss the metabolism of Deutetrabenazine.
- Elimination: Understand how Deutetrabenazine is eliminated from the body.
- Half-life: Know the half-life of Deutetrabenazine and its clinical significance.
Drug Interactions:
- Identify common drug interactions with Deutetrabenazine and strategies for managing them.
- Understand the mechanisms through which these interactions occur.
- Know which medications should be avoided with Deutetrabenazine due to drug interactions.
Common Side Effects:
- Learn about the most common side effects of Deutetrabenazine.
- Understand potential life-threatening side effects and how to manage them.
- Educate patients on what to expect and how to manage side effects.
Contraindications:
- Learn the conditions under which Deutetrabenazine should not be used.
- Understand the reasons why these conditions are contraindicated.
Best Augmenting Combos for Partial Response:
- Learn about the best augmenting combinations for patients with a partial response to Deutetrabenazine.
- Discover effective strategies for augmenting Deutetrabenazine therapy.
- Evaluate the efficacy and safety of common augmentation strategies.
Recommended Lab Tests:
- Learn about recommended lab tests for safe and effective monitoring.
- Identify necessary lab tests to monitor patients on Deutetrabenazine.
- Interpret lab results to guide treatment adjustments.
Therapeutic Monitoring:
- Apply strategies for therapeutic monitoring to optimize treatment outcomes.
- Know about the therapeutic blood levels for Deutetrabenazine.
Overdose:
- Understand the signs and symptoms of Deutetrabenazine overdose.
- Recognize early warning signs of overdose and effective management strategies.
Tapering/Withdrawal:
- Apply best practices for tapering and withdrawal of Deutetrabenazine to minimize withdrawal symptoms.
- Follow the best protocols based on decades of clinical practice to safely taper Deutetrabenazine.
- Educate patients on the process and expected symptoms of tapering.
Usage with Special Populations:
- Gain insights into the unique considerations for prescribing Deutetrabenazine to special populations such as pregnancy, lactation, hepatic impairment, renal impairment, cardiac impairment, elderly, and children.
- Tailor Deutetrabenazine dosage for special populations considering their unique needs.
- Understand the risks and benefits of Deutetrabenazine use in these populations.
Important Pearls:
- Learn about essential clinical pearls to enhance practice and ensure patient safety.
- Understand the most important facts about Deutetrabenazine based on decades of clinical practice.
- Apply practical tips and experiences from clinical practice to improve patient outcomes.
