Return to course: Desipramine (Norpramin) Medication

Desipramine (Norpramin) Medication

Lessons

Desipramine Brand Names & Introduction

Desipramine Indications

Desipramine Dosage & Adminstration

Desipramine Pharmacological Effects

Desipramine Pharmacokinetics & Warning

Desipramine Drug Interactions

Desipramine Common Side Effects

Desipramine Contraindication & Augmentation For Partial Response

Desipramine Recommended Lab Test & Overdose

Desipramine Tapering/Withdrawal

Desipramine Special Populations

Desipramine Important Pearls

Desipramine Quiz

Q1. Desipramine belongs to which class of antidepressants?

A) Tricyclic antidepressants (TCAs)

B) Selective serotonin reuptake inhibitors (SSRIs)

C) Monoamine oxidase inhibitors (MAOIs)

D) Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Q2. Which neurotransmitter system is primarily affected by Desipramine?

A) Norepinephrine

B) Serotonin

C) Dopamine

D) GABA

Q3. What is the starting dose of Desipramine for treating depression?

A) 25 mg once daily

B) 50 mg once daily

C) 75 mg once daily

D) 100 mg once daily

Q 4.Which serious side effect is associated with Desipramine, particularly at high doses?

A) QT prolongation

B) Seizures

C) Hepatotoxicity

D) Nephrotoxicity

Q5.Desipramine is contraindicated in patients with which of the following conditions?

A) Recent myocardial infarction

B) Controlled hypertension

C) Mild renal impairment

D) Hyperlipidemia

Q6. Which enzyme is primarily responsible for the metabolism of Desipramine?

A) CYP2D6

B) CYP3A4

C) CYP1A2

D) CYP2C19

Q7.Which off-label use is commonly associated with Desipramine?

A) Neuropathic pain

B) Psychosis

C) Sleep disorders

D) Attention deficit hyperactivity disorder (ADHD)

8.What is the black box warning associated with Desipramine?

A) Increased risk of suicidal thinking and behavior in children, adolescents, and young adults

B) Risk of serotonin syndrome

C) Hepatotoxicity

D) Risk of hypertensive crisis

Q 9.Which augmentation strategy may be used with Desipramine for partial response in depression?

A) Antipsychotics

B) Mood stabilizers

C) Psychostimulants

D) All of the above

Q10. Which serious drug interaction should be avoided with Desipramine?

A) MAO inhibitors

B) Benzodiazepines

C) Beta-blockers

D) Antihistamines

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