Return to course: Doxepin (Sinequan, Silenor) Medication

Doxepin (Sinequan, Silenor) Medication

Lessons

Doxepin Brand Name & Introduction

Doxepin Indications

Doxepin Dosage & Adminstration

Doxepin Pharmacological Effects

Doxepin Pharmacokinetics & Warning

Doxepin Drug Interactions

Doxepin Common Side Effects

Doxepin Contraindication & Augmentation For Partial Response

Doxepin Recommended Lab Test & Overdose

Doxepin Tapering/Withdrawal

Doxepin Special Populations

Doxepin Important Pearls

Doxepin Quiz

“This quiz will evaluate your knowledge about Doxepin medication.”

Q1. Doxepin belongs to which class of antidepressants?

A) Tricyclic antidepressants (TCAs)

B) Selective serotonin reuptake inhibitors (SSRIs)

C) Monoamine oxidase inhibitors (MAOIs)

D) Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Q2. Doxepin is also FDA-approved for the treatment of which condition, besides depression?

A) Insomnia

B) Anxiety disorders

C) Chronic pain

D) Post-traumatic stress disorder (PTSD)

Q3. What is the recommended starting dose of Doxepin for treating depression?

A) 25 mg once daily

B) 50 mg once daily

C) 75 mg once daily

D) 100 mg once daily

Q4. Which side effect is most commonly associated with Doxepin use?

A) Sedation

B) Weight gain

C) Hypertension

D) Insomnia

Q5. Doxepin is contraindicated in patients with which of the following conditions?

A) Glaucoma

B) Controlled hypertension

C) Mild renal impairment

D) Hyperlipidemia

Q6. Which enzyme primarily metabolizes Doxepin?

A) CYP2D6

B) CYP3A4

C) CYP1A2

D) CYP2C19

Q 7.What is the black box warning associated with Doxepin?

A) Increased risk of suicidal thinking and behavior in children, adolescents, and young adults

B) Risk of serotonin syndrome

C) Hepatotoxicity

D) QT prolongation

Q8. Which drug interaction should be avoided with Doxepin due to the risk of severe sedation?

A) MAO inhibitors

B) Benzodiazepines

C) Beta-blockers

D) Antihistamines

Q9.Which condition is Doxepin often used off-label to treat?

A) Chronic pain

B) Psychosis

C) Sleep disorders

D) Attention deficit hyperactivity disorder (ADHD)

Q10. Which monitoring is recommended during long-term Doxepin therapy?

A) Liver function tests (LFTs)

B) Electrocardiogram (ECG)

C) Renal function

D) Complete blood count (CBC)

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