Return to course: Imipramine (Tofranil) Medication

Imipramine (Tofranil) Medication

Lessons

Imipramine Brand Name & Introduction

Imipramine Indications

Imipramine Dosage & Administration

Imipramine Pharmacological Effects

Imipramine Pharmacokinetics & Warnings

Imipramine Drug Interactions

Imipramine Common Side Effects

Imipramine Contraindications & Augmentation For Partial Response

Imipramine Recommended Lab Test & Overdose

Imipramine Tapering Withdrawal

Imipramine Special Populations

Imipramine Important Pearls

Imipramine Quiz

“This quiz will evaluate your knowledge about Imipramine medication.”

Q1. Imipramine belongs to which class of antidepressants?

A) Tricyclic antidepressants (TCAs)

B) Selective serotonin reuptake inhibitors (SSRIs)

C) Monoamine oxidase inhibitors (MAOIs)

D) Serotonin-norepinephrine reuptake inhibitors (SNRIs)

Q2. Which neurotransmitter systems are primarily affected by Imipramine?

A) Serotonin and norepinephrine

B) Dopamine and serotonin

C) GABA and glutamate

D) Acetylcholine and norepinephrine

Q3. What is the starting dose of Imipramine for treating depression?

A) 25 mg once daily

B) 50 mg once daily

C) 75 mg once daily

D) 100 mg once daily

Q4. Which serious side effect is associated with Imipramine, particularly at high doses?

A) QT prolongation

B) Seizures

C) Hepatotoxicity

D) Nephrotoxicity

Q5. Imipramine is contraindicated in patients with which of the following conditions?

A) Recent myocardial infarction

B) Controlled hypertension

C) Mild renal impairment

D) Hyperlipidemia

Q6. Which enzyme is primarily responsible for the metabolism of Imipramine?

A) CYP2D6

B) CYP3A4

C) CYP1A2

D) CYP2C19

Q7.Which off-label use is commonly associated with Imipramine?

A) Neuropathic pain

B) Psychosis

C) Sleep disorders

D) Attention deficit hyperactivity disorder (ADHD)

Q 8.What is the black box warning associated with Imipramine?

A) Increased risk of suicidal thinking and behavior in children, adolescents, and young adults

B) Risk of serotonin syndrome

C) Hepatotoxicity

D) Risk of hypertensive crisis

Q9. Which augmentation strategy may be used with Imipramine for partial response in depression?

A) Antipsychotics

B) Mood stabilizers

C) Psychostimulants

D) All of the above

Q 10. Which serious drug interaction should be avoided with Imipramine?

A) MAO inhibitors

B) Benzodiazepines

C) Beta-blockers

D) Antihistamines

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